Document Type

Paper- Restricted to Campus Access

Publication Date

4-29-2026

Faculty Mentor

Stephen Kolwicz

Abstract

Acute exercise induces numerous molecular response, including changes in gene expression that may last long after exercise is completed. Of interest, the majority of these research studies have been limited to the 24-hour post-exercise time point. We previously published a study that showed, in mouse skeletal muscle, changes in metabolic gene expression persisted up to 24 hours but returned to baseline within 48 to 72-hours after exercise. In the present study, we examined the cardiometabolic gene response to acute exercise in mice. Male and female mice performed one bout of acute exercise on a motorized treadmill for 60 minutes at a speed of 15m/min at a 10% incline. An additional group of non-exercised, male and female mice served as sedentary (SED) controls. Hearts were collected at 30 minutes, 24, 48, and 72 hours after the exercise session. To determine changes in gene expression, RNA was extracted from the LV tissue, and cDNA was synthesized. Prominent genes involved in glucose, fatty acid, ketone body, and mitochondrial-related metabolism were measured by RT-PCR. The results showed that, similar to the previous study in skeletal muscle, gene expression changes returned to baseline within 48 to 72 hours after exercise.

Comments

This work was supported by an Academic Research Enhancement Award (AREA, #R15HL177624) from the National Institutes of Health (NIH).

Presented as part of the Ursinus College Celebration of Student Achievement (CoSA) held April 29, 2026.

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