Submission Date

7-24-2026

Document Type

Paper- Restricted to Campus Access

Department

Chemistry

Faculty Mentor

Julianne M. Yost

Student Contributor

Grace M. DiGiacomo

Second Student Contributor

Emily Rychlak

Comments

Presented during the 28th Annual Summer Fellows Symposium, July 24, 2026 at Ursinus College.

Project Description

Suzuki–Miyaura cross-coupling reactions are one of the most utilized coupling reactions chemists use to form new carbon–carbon bonds and are widely used in the development of various pharmaceuticals and synthesis of natural products. Pinacol boronic esters are typically utilized as the in Suzuki reactions, but due to their low relative reactivity in comparison to other boron reagents, this often necessitates harsher and less sustainable reaction conditions. Many reactions involving pinacol boronic esters rely on elevated temperatures and solvents that are less desirable from a green chemistry perspective. This project identified more environmentally green conditions in Suzuki cross-coupling reactions through a survey of potential catalysts, solvents, and bases. We evaluated numerous reaction parameters and their influence on reaction conversion. Ultimately, we were able to decrease temperature, catalyst loading, reaction time, and swapped to an eco-friendlier solvent.

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