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Force transducers are used to measure the force of muscle contraction after electrical stimulation. Here, we attempted to use relatively inexpensive materials to produce data from a force transducer ex vivo. After cervical dislocation of the mouse, the tibialis anterior was isolated and the leg was cut at the distal femur. The proximal tibia and fibula were removed so that the tibialis anterior was left attached to the patella. Using a 4.0 suture, a box knot was tied on the distal tendon of the tibialis anterior. The suture was used to attach the muscle to the force transducer and position the muscle for electrical stimulation. After isolating the tibialis anterior, the force of contraction was recorded. We were successful in attaching the muscle to the force transducer and recording reproducible data. We plan to use this technique to determine how different treatments restore normal muscle force following injury.
Pierson, Julia and Lee, Hannah N., "Method of Experimental Force Transduction: Audio Commentary" (2020). Biology Presentations. 6.
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