Submission Date
5-3-2024
Document Type
Paper
Department
Physics & Astronomy
Adviser
Casey Schwarz
Committee Member
Ross Martin-Wells
Committee Member
Doron Taussig
Department Chair
Casey Schwarz
External Reviewer
Rashi Sharma
Distinguished Honors
This paper has met the requirements for Distinguished Honors.
Project Description
Bioactive glass beads were discovered for their bone repair properties in 1969. This properties, along with their bactericidalness, high ability to be engineered, bioactiveness and their versatile structures, mark them as excellent candidates for explorations in other biomedical applications in addition to bone repair. One alternative application includes passive drug delivery, especially when the biomaterial is in a porous, microsphere structure. In this work, we first explore various samples of bioactive glass compositions and structures in order to target the best bead for the application of drug delivery. The targeted beads are then thoroughly characterized using optical microscopy, Scanning Electron Microscopy (SEM), Raman Spectroscopy, X-Ray Diffraction (XRD), and White Light Interferometry. Next, our work focuses on the development of a novel absorbance measuring process and analysis in order to track passive diffusion of dye loaded beads in solution. This serves as a platform for correlating passive drug diffusion rates with material properties and performance as a route to functional applications.
Recommended Citation
Sykes, Marie O., "Bioactive Glass Bead Characterization: Further Applications in Passive Drug Delivery" (2024). Physics and Astronomy Honors Papers. 13.
https://digitalcommons.ursinus.edu/physics_astro_hon/13
