Submission Date

7-24-2020

Document Type

Paper- Restricted to Campus Access

Department

Neuroscience

Second Department

Biology

Faculty Mentor

Carlita Favero

Comments

Presented during the 22nd Annual Summer Fellows Symposium, July 24, 2020 at Ursinus College.

A related presentation is available here.

Project Description

Fetal Alcohol Spectrum Disorder (FASD) is an overarching term used to describe the range of physical, mental, behavioral, and/or learning disabilities that become present in an individual who was exposed to alcohol in the womb. Structural and functional effects on the brain from alcohol exposure prenatally is contingent upon many factors strongly correlating to the timing and duration of the exposure. The hippocampus is one of the most alcohol sensitive brain formations because of the intense cellular responsiveness to the extracellular environment and its role in learning and memory. The effects of alcohol exposure may be due to changes at the molecular level which can effectually lead to a change in axon guidance in the hippocampus. This review synthesizes information on axon guidance mechanisms in the hippocampus as well as the consequences of alcohol exposure on these mechanisms.

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