Submission Date

7-18-2025

Document Type

Paper- Restricted to Campus Access

Department

Health & Exercise Physiology

Faculty Mentor

Stephen Kolwicz

Comments

Presented during the 27th Annual Summer Fellows Symposium, July 18, 2025 at Ursinus College.

Project Description

Approximately 13% of adults in the US are prescribed antidepressant medications. Selective Serotonin Reuptake Inhibitors (SSRIs) are one of the most commonly prescribed antidepressant medications, with fluoxetine (i.e., Prozac) being one of the most well-known. Previous literature has established some interesting yet inconclusive findings with SSRI use on exercise performance and skeletal muscle including enhanced fatigue, decreased muscle weight, and enhanced substrate and mitochondrial metabolism. The purpose of this study was to evaluate the effects of oral administration of fluoxetine on physical activity in mice.

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