Document Type

Paper- Restricted to Campus Access

Publication Date

4-29-2026

Faculty Mentor

Stephen Kolwicz

Abstract

Previous studies in the laboratory showed that one bout of exercise led to an upregulation of several metabolic genes in the skeletal muscle 30 minutes after exercise, which returned to baseline within 48-72 hours of recovery. However, in that study, measurements of blood metabolites were not assessed immediately after acute exercise or during the recovery period. Therefore, the goal of this study was to measure the changes in key metabolites (i.e., glucose, lactate, and ketone bodies) in response to acute exercise.  To test this, our experiment consisted of running 18 male and female C57BL/6NCrl mice (n = 9 each group) for 60 minutes on a motorized treadmill at a moderate intensity (15 m/min, 10-degree incline). Blood glucose, ketone bodies, and lactate were collected from the tail tip immediately post-exercise (IPEX), 15 minutes, 30 minutes, and 60 minutes after exercise and measured with commercially available handheld meters. A group of non-exercise sedentary male (n = 9) and female (n = 9) mice was used as controls. The findings of this study established how glucose, lactate, and ketone bodies change in response to acute exercise of moderate intensity and how quickly they return to baseline levels.

Comments

This work was supported by an Academic Research Enhancement Award (AREA, #R15HL177624) from the National Institutes of Health (NIH).

Presented as part of the Ursinus College Celebration of Student Achievement (CoSA) held April 29, 2026.

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