Document Type

Paper- Restricted to Campus Access

Publication Date

4-24-2024

Faculty Mentor

Stephen C. Kolwicz, Jr.

Abstract

Approximately 13% of adults in the US are prescribed antidepressant medications. Selective Serotonin Reuptake Inhibitors (SSRIs) are one of the most commonly prescribed antidepressant medications, with fluoxetine (i.e., Prozac) being one of the most well-known. Previous literature has established some interesting yet inconclusive findings with SSRI use on exercise performance and skeletal muscle including enhanced fatigue, decreased muscle weight, and enhanced substrate and mitochondrial metabolism. The purpose of this pilot study was to develop a treatment intervention strategy of oral administration of fluoxetine in mice. Oral administration via drinking water was chosen to best mimic the clinical use of fluoxetine and avoid stress caused by daily injections. For the study, we administered 10-12 mg/kg/day of fluoxetine, dissolved in drinking water, to male and female mice at 14 weeks of age for 6 weeks. Mice were evaluated on a weekly basis that included measurement of water intake and body weight. Tissues were harvested and weighed. NMR spectroscopy was used to assess the presence of fluoxetine in the serum.

Comments

Presented as part of the Ursinus College Celebration of Student Achievement (CoSA) held April 24, 2024.

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