Document Type

Paper- Restricted to Campus Access

Publication Date

4-22-2021

Faculty Mentor

Stephen Kolwicz

Abstract

Ketogenic diets and ketone body supplements are popular for combating obesity and improving weight loss or enhancing exercise performance, but the literature results are controversial. However, because the ketogenic diet is very low in carbohydrates, the diet could be an effective strategy for controlling blood glucose levels in type I diabetes. Therefore, the purpose of this study is to evaluate the effects of the ketogenic diet on type I diabetes in male mice. Twenty male mice were randomly assigned to control group or injected with streptozotocin (STZ) to induce type I diabetes. STZ mice were injected with 150 mg/kg body weight. After one week, control and STZ mice were randomly assigned to either chow or ketogenic diet for four weeks (n=5 in each group). Mice were weighed weekly to evaluate changes in body weight and blood glucose was checked at two-week intervals. At the end of four weeks, gravimetric analysis on heart, liver, and adipose tissue was performed to evaluate changes in organs due to diet. The findings of this pilot study could provide some insight into whether the ketogenic diet is a suitable intervention for type I diabetes.

Comments

Presented as part of the Ursinus College Celebration of Student Achievement (CoSA) held April 22, 2021.

The downloadable .mp4 video file is a poster presentation with audio commentary with a run time of 3:37.

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