Submission Date

7-24-2026

Document Type

Paper- Restricted to Campus Access

Department

Chemistry

Faculty Mentor

Julianne M. Yost

Student Contributor

Emily Rychlak

Second Student Contributor

Ayan S. Zaman

Comments

Presented during the 28th Annual Summer Fellows Symposium, July 24, 2026 at Ursinus College.

Project Description

Indoles are privileged scaffolds in medicinal chemistry and are widely found in biologically active natural products and pharmaceuticals. These nitrogen-containing heterocycles serve as versatile frameworks for the design and development of novel drugs in the human body and have diverse biological activities, including anticancer, anti-inflammatory, and antibacterial effects. A common strategy for functionalizing the indole scaffold is the Suzuki–Miyaura cross-coupling reaction. However, conventional reaction conditions often rely on environmentally harmful solvents, high temperatures, and prolonged reaction times. To develop more sustainable reaction conditions, various catalysts, solvents, and bases were systematically screened while reducing reaction temperature and time. The optimized conditions were then applied to a substrate scope study.

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