Submission Date

7-19-2024

Document Type

Paper- Restricted to Campus Access

Department

Chemistry

Faculty Mentor

Ryan R. Walvoord

Comments

Presented during the 26th Annual Summer Fellows Symposium, July 19, 2024 at Ursinus College.

Project Description

Reactivity-based probes are commonly used in various imaging types to detect analytes or biomolecules such as proteins of interest. By tagging the molecule of interest, the probe will elicit either a fluorogenic or colorimetric response, allowing for sensitive visualization using microscopy. Current reactivity-based probes, while useful, are not without their limitations, inviting efforts to develop new chemical tools with improved solubility, selectivity, biocompatibility, and photophysical properties and allowing for better detection of molecules of interest. This research will focus on testing the reactivity and properties of a nitroso-containing fluorophore to determine its possible applications. Here, various types of reactions will be investigated as possible reaction motifs that may quickly and efficiently produce a change in the fluorophore's properties. The reaction profiles and efficiencies will be explored, and the properties of the products will then be analyzed. Ultimately, this project will provide an understanding of the nitroso group’s ability to produce new reaction-based detection tools.

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