Submission Date

7-21-2023

Document Type

Paper- Restricted to Campus Access

Department

Chemistry

Faculty Mentor

Ryan R. Walvoord

Comments

Presented during the 25th Annual Summer Fellows Symposium, July 21, 2023 at Ursinus College.

Project Description

Chlorite is a common water contaminant that is most commonly introduced to drinking water sources through wastewater disinfection and textile bleaching. Consumption of elevated levels of chlorite have been shown to produce adverse health effects, including birth defects and damage to red blood cells. Current analysis and detection of chlorite in water is complicated due to reliance on expensive and immobile instrumentation. Activity-based fluorogenic probes are a simple, inexpensive method for detecting ions and other molecules. These probes undergo a chemical reaction induced by interaction with a target analyte and produce a spectroscopic change. This project proposes to test whether an aldehyde-bearing fluorophore can undergo a selective Pinnick oxidation to produce a fluorogenic response. Efforts toward the synthesis of three fluorogenic probes and their response to chlorite will be presented.

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