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Owing to their biocompatibility, ease of chemical modification, and molecular programmability, oligonucleotides have been recognized as powerful building blocks for the assembly of dynamic nanostructures. In particular, modification of oligonucleotides with hydrophobic moieties has led to the development of drug delivery vehicles and oligonucleotide-based therapeutics with amphiphilic character. As a result, amphiphilic oligonucleotide conjugates have improved encapsulation of hydrophobic drugs, internalization of oligonucleotide-based therapeutics, and stability of nanoparticles. In this review, we examine different types of hydrophobic moieties that have been conjugated to oligonucleotides including lipids, polymers, cholesterols, and dendrimers. We discuss various applications of these conjugates including encapsulation of hydrophobic molecules and delivery of oligonucleotide-based therapeutics. We also consider the challenges associated with using these conjugates in a clinical setting.
Wun, Jesse and Martin, Kailey, "Amphiphilic Oligonucleotide Nanostructures for Drug Delivery and Therapeutic Applications" (2020). Chemistry Summer Fellows. 34.
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