Submission Date

7-24-2020

Document Type

Paper- Restricted to Campus Access

Department

Chemistry

Faculty Mentor

Samantha Wilner

Comments

Presented during the 22nd Annual Summer Fellows Symposium, July 24, 2020 at Ursinus College.

A related presentation is available here.

Project Description

Owing to their biocompatibility, ease of chemical modification, and molecular programmability, oligonucleotides have been recognized as powerful building blocks for the assembly of dynamic nanostructures. In particular, modification of oligonucleotides with hydrophobic moieties has led to the development of drug delivery vehicles and oligonucleotide-based therapeutics with amphiphilic character. As a result, amphiphilic oligonucleotide conjugates have improved encapsulation of hydrophobic drugs, internalization of oligonucleotide-based therapeutics, and stability of nanoparticles. In this review, we examine different types of hydrophobic moieties that have been conjugated to oligonucleotides including lipids, polymers, cholesterols, and dendrimers. We discuss various applications of these conjugates including encapsulation of hydrophobic molecules and delivery of oligonucleotide-based therapeutics. We also consider the challenges associated with using these conjugates in a clinical setting.

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