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Fluorescent probes are used in chemical, biological, and environmental studies as a means of detecting the presence of a desired target molecule. These probes, when reacted with their target molecule, “turn on” and emit light when excited with energy. This emitted light can be detected and provides a positive indicator of the target molecule. These fluorophores are extremely useful because they can be fine-tuned to be highly sensitive and selective toward their target. However, there is a lack of ability to predict brightness of fluorescent compounds based on their structure. Thus, significant synthetic effort is currently required to create effective fluorescent tools. Through the systematic investigation of structural and electronic factors by chemically modifying the structure of such fluorophores, the goal of this research is to provide the scientific community with a library of data as a means to understand and rationally design fluorescent probes.
Balestriere, Matthew, "Towards the Rational Design of Photoinduced Electron Transfer (PET)-Based Fluorescent Probes" (2019). Chemistry Summer Fellows. 27.
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