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Fluorophores are compounds that absorb and re-emit light that have important roles in subjects such as environmental testing, biological imaging, and forensics. Currently, we are limited in the amount of fluorophores that we can make and utilize for these purposes. This work seeks to combat this issue by creating a simple, general, and efficient method for the synthesis of amino-conjugated fluorophores. This is mainly done through the conversion of hydroxyl fluorophores to amino fluorophores. These amino fluorophores have notable benefits over hydroxyl fluorophores such as pH insensitivity and photostability. Our synthetic strategy involved an alkylation-Smiles rearrangement -hydrolysis sequence. Currently, this method has been applied to three fluorophores, 7-hydroxy-4-methylcoumarin, 7-hydroxy-4-trifluoromethylcoumarin, and umbelliferone.
Elghawy, Omar, "The Alkylation and Subsequent Smiles Rearrangement of Hydroxycoumarin Derivatives" (2017). Chemistry Summer Fellows. 13.