Submission Date
7-21-2017
Document Type
Paper- Restricted to Campus Access
Department
Chemistry
Faculty Mentor
Ryan Walvoord
Project Description
Fluorophores are compounds that absorb and re-emit light that have important roles in subjects such as environmental testing, biological imaging, and forensics. Currently, we are limited in the amount of fluorophores that we can make and utilize for these purposes. This work seeks to combat this issue by creating a simple, general, and efficient method for the synthesis of amino-conjugated fluorophores. This is mainly done through the conversion of hydroxyl fluorophores to amino fluorophores. These amino fluorophores have notable benefits over hydroxyl fluorophores such as pH insensitivity and photostability. Our synthetic strategy involved an alkylation-Smiles rearrangement -hydrolysis sequence. Currently, this method has been applied to three fluorophores, 7-hydroxy-4-methylcoumarin, 7-hydroxy-4-trifluoromethylcoumarin, and umbelliferone.
Recommended Citation
Elghawy, Omar, "The Alkylation and Subsequent Smiles Rearrangement of Hydroxycoumarin Derivatives" (2017). Chemistry Summer Fellows. 13.
https://digitalcommons.ursinus.edu/chem_sum/13
Restricted
Available to Ursinus community only.
Comments
Presented during the 19th Annual Summer Fellows Symposium, July 21, 2017 at Ursinus College.