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Members of the Slitrk family have become prominent candidates as sources for neuropsychiatric disorders (Proneca et al., 2011). Of interest in our study is Slitrk2 - a significant postsynaptic transmembrane protein that is involved in the formation of excitatory synapses. It is also medically relevant due to its link to schizophrenia (Piton et al., 2011). Slitrk2 has known intracellular binding partners such as PSD-95 in mouse brain and yeast cells (Loomis et al., 2020). However, there is insufficient knowledge on the functional significance of these intracellular binding partners. By examining the interaction between PSD-95 and Slitrk2 in mammalian cells (COS cells), our research allows us to perform mutant analysis, which ultimately helps us to better understand how Slitrk2 is trafficked to the synapse.
DeRosa, Melanie and Kanjanda, Simba, "Investigating Protein Interactions Important for Synapse Formation in the Developing Nervous System" (2021). Biology Summer Fellows. 85.
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