Submission Date

7-21-2017

Document Type

Paper- Restricted to Campus Access

Department

Biology

Faculty Mentor

Rebecca Lyczak

Comments

Presented during the 19th Annual Summer Fellows Symposium, July 21, 2017 at Ursinus College.

Supported by a Howard Hughes Medical Institute (HHMI) grant.

Project Description

In order for the single celled embryo of C. elegans to develop, they need to have a proper anterior-posterior axis development. A gene that plays an important role in that development is pam-1 which codes for the puromycin sensitive aminopeptidase (pam-1) protein. This protein cuts down on unknown targets which allow for proper anterior-posterior axis and embryonic development. Our study focuses on the mutated pam-1 gene which leads to a buildup of unknown targets which then results in embryonic lethality. In order to determine the unknown targets, we study the suppressors of pam-1, specifically lz6. The goal is to determine the chromosomal location of lz6.

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