Investigating the Capacity of TDP-43 Low Complexity Domain to Target Protein Aggregates in Yeast

Author

Nicholas J. Grahame, Ursinus CollegeFollow

Submission Date

7-17-2025

Document Type

Paper

Department

Biology

Second Department

Neuroscience

Faculty Mentor

Erica Gorenberg

Student Contributor

Ella Roche

Comments

Presented during the 27th Annual Summer Fellows Symposium, July 18, 2025 at Ursinus College.

Project Description

Utilizing protein TDP-43 and fluorescent proteins to:

Investigate TDP-43’s LCD region in protein aggregates. Use fluorescent protein tagging to visualize co-localization and aggregation. Leverage yeast as a model system for studying LLPS and aggregation.

Can we target chaperone proteins to TDP-43 LCD region?

Recommended Citation

Grahame, Nicholas J., "Investigating the Capacity of TDP-43 Low Complexity Domain to Target Protein Aggregates in Yeast" (2025). Biology Summer Fellows. 120.
https://digitalcommons.ursinus.edu/biology_sum/120