Document Type

Paper- Restricted to Campus Access

Publication Date

4-23-2025

Faculty Mentor

April Carpenter

Abstract

The purpose of our study was to investigate how cryotherapy treatment changes the inflammatory process following muscle injury. Male and female mice were injected with either 20ul of either 0.9% NaCl (control) or 1.2% BaCl2 (injury). Immediately following injection, mice were either given no treatment, or a 20 minute treatment with ice under anesthesia. We found that the temperature between the muscle and the ice packs was lowest (-2.80C°) around 4 minutes into cryotherapy treatment and highest at the end of treatment (7.40C°). At 48 hours following injection, the tibialis anterior and blood was removed from the mouse and snapped frozen. Next semester we will use these samples to determine if cryotherapy changes inflammatory protein levels in males and females. We will also compare any observed changes in inflammatory protein profiles to those from a different experiment where mice underwent three cryotherapy treatments.

Comments

Presented as part of the Ursinus College Celebration of Student Achievement (CoSA) held April 23, 2025.

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