Paper- Restricted to Campus Access
Our research will focus on BV-2 microglia cells, which will be exposed to a protein found in SARS-CoV-2, known as S1 glycoprotein, and measuring multiple factors in order to better understand how this protein interacts with microglial cells. The S1 glycoprotein is a spike protein that is present on the outer envelope of the SAR-CoV-2 virus and allows the virus to recognize other cells, and results in infection of these cells, as well as allowing the virus to cross the blood brain barrier (Rhea et al. 2020). This protein is a crucial component in the infection of microglial cells by COVID-19, and therefore our research will be observing how this protein functionally impacts microglial cells. The specific aims of our study will include (1) to determine how the phagocytic activity changes upon exposure to S1 glycoprotein and (2) to examine immune activation through cytokine release when exposed to the S1 glycoprotein.
Burns, Courtney, "The Impact of SARS-CoV-2 S1 Glycoprotein on the Phagocytic Activity of Microglia Cells" (2021). Biology Presentations. 33.
Available to Ursinus community only.