Document Type

Paper- Restricted to Campus Access

Publication Date

4-22-2021

Faculty Mentor

April Carpenter

Abstract

Skeletal muscle injury is common and limits lifestyle habits that reduce disease. Mechanical stress on the muscle caused by physical activity has many benefits including the strengthening of surrounding bone; however, overuse or muscle strain can lead to damage of contractile components, decreasing the magnitude of contraction. The amount of force generated by a muscle can be used as a measure of muscle injury and healing. Studying the functional response of skeletal muscle after injury allows comparison of external treatment factors which can affect the rate and degree of tissue regeneration. Using an ex vivo procedure, a more affordable and accessible method of generating contractile force than in situ analysis, contractile force was measured. This assessment was conducted on a mouse model using barium chloride (BaCl2) to mimic mechanical injury. The contractile strength of the tibialis anterior (TA) was measured at 11 days post-injury in both male and female models using the AD Instruments Wide Range Force Transducer. We found that fatigue as a response of electrical stimulation is a viable method to measure muscle regeneration.

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Presented as part of the Ursinus College Celebration of Student Achievement (CoSA) held April 22, 2021.

The downloadable file is a poster presentation with audio commentary with a run time of 1:33.

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