Submission Date

4-23-2016

Document Type

Paper- Restricted to Campus Access

Department

Biology

Adviser

Dale Cameron

Committee Member

Anthony Lobo

Committee Member

Dale Cameron

Committee Member

Lisa Grossbauer

Department Chair

Peter Small

Project Description

This study hopes to understand the function and possible consequences of prion proteins using Saccharomyces cerevisae and the [PSI+] phenotype as a model. Specifically, this experiment examines prion dependent changes in normal protein expression and in disabled open reading frames (dORFs) such as Pau7 and whether phenotypic changes caused by the [PSI+] prion yields a fitness advantage against normal cells under conditions of extreme environmental stress.

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