Submission Date

5-1-2024

Document Type

Paper

Department

Biology

Adviser

Jennifer King

Committee Member

Joel Bish

Committee Member

Cory Straub

Department Chair

Dale Cameron

Project Description

Microglia and their role as the immune cells of the central nervous system are an emerging area of interest within Alzheimer’s research, particularly as they have shown in a benevolent and malevolent cellular context. Models of Alzheimer’s disease are very light in studying microglia, so in this study a model of microglia isolated from aged mice is established in order to study the phagocytic activity and protein expression of microglia in response to Amyloid Beta. The cells were isolated from aged mice and cultured before being used to confirm cellular identity, as well as to measure phagocytic activity. This study has successfully established this model for further study into the role of microglia within AD as well as other diseases.

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