Submission Date


Document Type

Paper- Restricted to Campus Access


Health & Exercise Physiology


Stephen Kolwicz

Committee Member

April Carpenter

Committee Member

Beth Bailey

Department Chair

Del Engstrom

Project Description

Insulin is a hormone that is critical in the maintenance of blood glucose, which is a critical source of energy for all cells. In type 1 diabetics, glucose homeostasis is impaired because of a lack of sufficient insulin production. The continual reliance on external insulin may disrupt the insulin signaling pathway, which contributes to insulin resistance. According to studies, exercise training is an effective treatment to regulate insulin resistance in type 1 diabetics. The purpose of this study was to examine the effects of exercise training on blood glucose homeostasis and insulin signaling in type 1 diabetic mice. C57BL/6-Ncrl mice were injected with a compound streptozotocin (STZ) to induce type 1 diabetes. After 2 weeks, mice were exercise trained on a treadmill for 60 minutes a day for 5 days a week for 4 weeks. At the end of 4 weeks, mice were then subjected to a glucose tolerance test to assess blood glucose homeostasis. Serum was collected and blood chemistry analysis of insulin and hemoglobin A1c were conducted. Skeletal muscle and heart were harvested to analyze genes involved in the insulin signaling pathway. The results demonstrate that STZ causes hyperglycemia, dyslipidemia, body weight, fat loss, and skeletal muscle atrophy. Exercise training in STZ mice does not improve any of the negative side effects of type 1 diabetes in female mice.