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Small molecule fluorescent probes are commonly used in imaging applications and sensors including detecting environmental analytes or elucidating biological phenomena. Many of these compounds function via a change in brightness occurring through photoinduced electron transfer (PeT). Although this concept is well understood, PeT-based probes are almost entirely developed via empirical methods. The current project focuses on synthesizing a series of naphthalene and coumarin-based fluorescent probes bearing carefully altered quenching moieties. The photophysical properties of these molecules will then be determined. Ultimately, this systematic investigation of structure-optical property relationship aims to provide the scientific community with a more rational means for creating these useful chemical tools.
Dorsheimer, Julia, "Toward the Rational Design of Photo-induced Electron Transfer (PET)-Based Fluorescent Probes" (2018). Chemistry Summer Fellows. 23.