Submission Date

5-6-2021

Document Type

Paper- Restricted to Campus Access

Department

Chemistry

Adviser

Mark Ellison

Committee Member

Samantha Wilner

Committee Member

Anthony Lobo

Department Chair

Amanda Reig

Project Description

Antibiotic resistance poses a serious health risk all over the globe. It significantly decreases the efficacy of some of our most prized creations: antibiotics. Many approaches to combat this crisis have been sought out, with a more recent one being drug delivery through carbon nanotubes. However, the use of carbon nanotubes as vehicles in these systems has been limited to cancer research and molecules with conjugated p systems. This study aims to create a carbon nanotube drug delivery system for clarithromycin that has the potential to be applied to a wider scope of antibiotics. The proposed system contains two components, a cysteine functionalized carbon nanotube and a cysteine-clarithromycin conjugate, that can be reversibly linked together through a disulfide bond. Thus far, we have been successful in synthesizing an effective cysteine-clarithromycin conjugate and developing a revised synthesis for cysteine functionalized carbon nanotubes.

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