Dosage-Dependent, Carboplatin and NG52 Show Synergistic Effect on Inhibiting Cell Proliferation in Breast Cancer Cell Line

Authors

Ben Couture, Ursinus CollegeFollow
Ryan Zhuge, Ursinus CollegeFollow

Document Type

Paper

Publication Date

4-23-2025

Faculty Mentor

Ramesh Dasari

Abstract

BT-549 (Breast Cancer), a highly invasive epithelial breast cancer cell line, was used to investigate the effects of two drugs: NG52, a selective kinase inhibitor and Carboplatin, a platinum-based DNA-alkylating agent. Using cell counting assays and calculating IC50 values, we examined their combined impact on cell proliferation. Results revealed both an antagonistic and synergistic effect dependent on concentration. Where the individual agents inhibited cell proliferation less effectively than expected. These findings show the complexity of drug interactions and provide insights into optimizing therapeutic strategies for highly invasive cancer types.

Comments

Presented as part of the Ursinus College Celebration of Student Achievement (CoSA) held April 23, 2025.

The downloadable file is a poster.

Recommended Citation

Couture, Ben and Zhuge, Ryan, "Dosage-Dependent, Carboplatin and NG52 Show Synergistic Effect on Inhibiting Cell Proliferation in Breast Cancer Cell Line" (2025). Biology Presentations. 47.
https://digitalcommons.ursinus.edu/biology_pres/47