Submission Date


Document Type

Paper- Restricted to Campus Access




Stephen Kolwicz

Committee Member

Beth Bailey

Committee Member

Simara Price

Department Chair

Dale Cameron

Project Description

Ketone bodies have been identified as an important fuel source during physiological and pathological stress. During exercise, augmenting ketone body metabolism in the skeletal muscle may enhance exercise performance while targeting ketone body metabolism in heart failure may improve cardiac function. Since the keto is a high-fat, low carbohydrate diet, this dietary strategy may have harmful effects on the heart particularly during ischemic injury. Therefore, the objective of this study was to investigate the effects of consumption of the ketogenic diet on cardiac ischemia-reperfusion injury. Male and female mice were randomly assigned to a ketogenic diet (Keto) or a normal chow diet for 6 weeks. After 6 weeks, cardiac function was assessed via Langendorff isolated heart perfusions during baseline and ischemia-reperfusion (I- R) conditions.


This project was funded by a grant from the American Heart Association.