Submission Date


Document Type





Dr. Rebecca Roberts

Committee Member

Dr. Rebecca Roberts

Committee Member

Dr. Anthony Lobo

Committee Member

Dr. Victor Tortorelli

Department Chair

Dr. Kathryn Goddard

Project Description

Systemic Lupus Erythematosis (SLE) is an autoimmune disease that causes the immune system to self-destruct. SLE is nine times more frequent in women than in men, and it has been shown that there is a correlation between high estrogen levels and an increased severity of the disease. This raises a concern about environmental estrogens, including Bisphenol A (BPA) which is found in many plastic products in the United States. BPA can be absorbed by the foods and liquids that are held in the plastic containers and then can enter into the human body. Because of its structural similarity to estrogen, BPA is able to bind to estrogen receptors, which could potentially lead to adverse effects on the body and autoimmune diseases such as SLE. This study investigated the role of BPA and other bisphenols on enzyme activity in a murine model for SLE.


This project was funded by the Ursinus College Biology Department, the Summer Fellows Program at Ursinus College, the Howard Hughes Medical Institute and the FUTURE program.

Available for download on Sunday, April 27, 2025