Submission Date
4-28-2025
Document Type
Paper- Restricted to Campus Access
Department
Biochemistry & Molecular Biology
Adviser
Mark Ellison
Committee Member
Mark Ellison
Committee Member
Lisa Grossbauer
Committee Member
Anthony Lobo
Department Chair
Eric Williamsen
Department Chair
Anthony Lobo
Project Description
As antibiotic resistance looms as a threat facing biomedical research and clinical settings it is imperative that researchers develop new methods to combat it. This paper reports the work conducted with the goal of utilizing covalently functionalized single-walled carbon nanotubes to combat antibiotic resistant bacteria strains. The covalently functionalized single-walled carbon nanotubes were developed as a key starting point towards creating a disulfide bond between nanotubes and antibiotics, with the intention of creating a cleavable disulfide bond that will act as a drug delivery mechanism. The goal of this work is to demonstrate this delivery mechanism and covalently functionalized carbon nanotubes can be leveraged against antibiotic resistant bacteria. This work presents a straightforward synthesis of cysteine functionalized single-walled carbona nanotubes as well as struggles encountered when attempting to create a cysteine-ampicillin conjugate with the intention of attaching the conjugate to our functionalized nanotubes.
Recommended Citation
Sugarman, Eric, "Investigating the Capability of Functionalized Single-Walled Carbon Nanotubes to Revitalize Antibiotics in Effort to Combat Antibiotic Resistance" (2025). Biochemistry and Molecular Biology Honors Papers. 23.
https://digitalcommons.ursinus.edu/biochem_hon/23
