Submission Date

7-22-2016

Document Type

Paper- Restricted to Campus Access

Department

Chemistry

Second Department

Biology

Faculty Mentor

Mark Ellison

Second Faculty Mentor

Anthony Lobo

Comments

Presented during the 18th Annual Summer Fellows Symposium, July 22, 2016 at Ursinus College.

Supported by a Howard Hughes Medical Institute (HHMI) grant.

Project Description

Graphene has emerged as an interesting compound because of its drug delivery potential. It is useful in drug delivery because it is water soluble and biocompatible. In our research, graphene was modified to synthesize nanoscale graphene oxide with biocompatible polyethylene glycol (PEG) to produce a stable, water-soluble recipient GO-PEG. GO-PEG is effective in delivering cancer drugs and shows promising success in the application of their versatility in biological systems. The goal of this experiment was to use GO to deliver insoluble tetracycline into antibiotic-resistant Escherichia coli colonies, and prevent proliferation. The ability of the GO-PEG TET to prevent proliferation of the sensitive and resistant strains was tested using a series of incubations, and was measured using spectrophotometry. We were able to confirm the success of the synthesis of GO-PEG with tetracycline by absorption and saw inhibition in both the non-resistant and resistant strain of E. coli.

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