Submission Date
4-25-2016
Document Type
Paper
Department
Chemistry
Adviser
Ronald Hess
Committee Member
Ronald Hess
Committee Member
Victor Tortorelli
Committee Member
Leah Joseph
Department Chair
Mark Ellison
Project Description
This work describes synthetic methodology development in organic chemistry. The goal of this work is to demonstrate new ways of making biologically-relevant molecules that are in line with the principles of green chemistry (chemical practices which seek to be, regarding human and environmental health, benign by design). To this end, a new method has been developed toward the introduction of primary amine functionalities into organic molecules from readily-available aldehydes, via reduction of nitroalkene intermediates. Traditional methods of reducing nitroalkenes to primary amines require harsh conditions, often produce stoichiometric amounts of metal salt waste, and present significant safety challenges to the chemist. The method described herein employs metal-catalysis to effect this same transformation under mild conditions.
Recommended Citation
Phillips, Brendan, "Catalytic Transfer Hydrogenation of Nitroalkenes to Primary Amines" (2016). Chemistry Honors Papers. 3.
https://digitalcommons.ursinus.edu/chem_hon/3
Included in
Environmental Chemistry Commons, Medicinal-Pharmaceutical Chemistry Commons, Organic Chemistry Commons
